Bone Abstracts

Angiogenesis is the main process mediating the expansion of the blood vessel network during development, tissue regeneration or in pathological conditions such as cancer. The formation of new endothelial sprouts, a key step in the angiogenic growth program, involves the selection of endothelial tip cells, which lead new sprouts. Angiogenic sprouting is induced by tissue-derived signals such as vascular endothelial growth factor (VEGF), which activates signaling by endothelial ...

Blood vessels define the properties of local microenvironments in the skeletal system, play crucial roles in osteogenesis and provide niches for haematopoietic stem cells. The properties of niche-forming vessels and their changes in the ageing organism remain incompletely understood. We have previously identified a new capillary subtype in the murine skeletal system with distinct morphological, molecular and functional properties. These vessels are CD31hi/Emcnh...

Blood vessels define the properties of local microenvironments in the skeletal system, play crucial roles in osteogenesis and provide niches for haematopoietic stem cells. The properties of niche-forming vessels and their changes in the ageing organism remain incompletely understood. We have previously identified a new capillary subtype in the murine skeletal system with distinct morphological, molecular and functional properties. These vessels are CD31hi/Emcnh...